Licensed from

methotrexate (generic name)

(METH oh TREX ate): An antipsoriatic - This medicine affects cells that are rapidly growing, such as cancer cells and cells in your mouth and stomach

methotrexate

What is this medicine?
METHOTREXATE (METH oh TREX ate) is a chemotherapy drug. This medicine affects cells that are rapidly growing, such as cancer cells and cells in your mouth and stomach. It is used to treat many cancers and other medical conditions. It is used for leukemias, lymphomas, breast cancer, lung cancer, head and neck cancers, and other cancers. This medicine also works on the immune system and is commonly used to treat psoriasis and rheumatoid arthritis. If used for arthritis or psoriasis, the drug is only given once a week.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What is the price of this medication and similar alternatives?

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 09/2009. For the most current and up-to-date pricing information, please visit www.drugstore.com. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Methotrexate 2.5MG Tablets DAVA PHARMACEUTICALS30/$31.99 or 60/$51.98
Methotrexate Sodium 25MG/ML PF) Solution (BEDFORD LABORATORIES10/$24.99 or 30/$61.97
Methotrexate Sodium 25MG/ML PF) Solution (BEDFORD LABORATORIES2/$14.99 or 4/$19.97
Methotrexate Sodium 25MG/ML PF) Solution (HOSPIRA40/$58.99 or 120/$158.51
Methotrexate Sodium 25MG/ML Solution HOSPIRA2/$13.99 or 6/$29.97
Methotrexate Sodium LPF 25MG/ML Solution MAYNE PHARMA2/$7.99 or 6/$17.51
Trexall 10MG Tablets TEVA PHARMACEUTICALS USA30/$447.6 or 90/$1276.66
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
  • bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine
  • changes in vision
  • diarrhea
  • difficulty breathing or a dry cough
  • mouth and throat ulcers
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • skin rash, hives, or itching
  • symptoms of infection like fever or chills, cough, sore throat, pain or difficulty passing urine
  • unusually weak or tired, fainting spells
  • vomiting
  • yellow coloring of skin or eyes

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizziness
  • drowsiness
  • loss of appetite
  • nausea

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I use this medicine?
Take this medicine by mouth. Swallow it with a full glass of water. Follow the directions on the prescription label. Do not take your medicine more often than directed. Finish the full course prescribed by your doctor or health care professional. Do not stop taking except on your doctor's advice.

If you take methotrexate for rheumatoid arthritis or psoriasis, the dose is given only once a week. Do not take more frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, talk with your doctor or health care professional. Do not take double or extra doses. If you vomit after taking a dose, call your doctor or health care professional for advice.
What may interact with this medicine?
  • antibiotics and other medicines for infections
  • aspirin and aspirin-like medicines including bismuth subsalicylate (Pepto-Bismol)
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • probenecid
  • trimetrexate
  • vaccines

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

Who should NOT use this medication?

  • Pregnant women with psoriasis or rheumatoid arthritis; use in treatment of neoplastic diseases only when potential benefit outweighs risk to fetus. (See Boxed Warning.)
  • Nursing women.
  • Excessive alcohol consumption, alcoholic liver disease, or other chronic liver disease in patients with psoriasis or rheumatoid arthritis.
  • Overt or laboratory evidence of immunodeficiency syndromes in patients with psoriasis or rheumatoid arthritis.
  • Preexisting blood dyscrasias (e.g., bone marrow hypoplasia, leukopenia, thrombocytopenia, clinically important anemia) in patients with psoriasis or rheumatoid arthritis.
  • Known hypersensitivity to methotrexate.

What should I watch for while using this medicine?
Visit your doctor or health care professional for checks on your progress. You will need to have regular blood checks. You will also need a chest X-ray before starting the medicine.

If you take the medicine for rheumatoid arthritis or psoriasis, you may not see an improvement in your condition for several weeks.

Do not drink alcohol-containing drinks while taking this medicine. Both alcohol and the medicine may cause damage to your liver.

This medicine may increase your risk of getting an infection. Stay away from people who are sick.

To protect your kidneys, drink water or other fluids as directed while you are taking this medicine.

Both men and women must use effective birth control. Use 2 reliable forms of birth control together. Do not become pregnant while taking this medicine. Women should continue to use birth control until after their first normal menstrual cycle after stopping the medicine. Call your doctor right away if you think you or your partner might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine. Men should continue to use birth control for at least 3 months after stopping the medicine.

If you are going to have surgery or dental work, tell your health care professional that you are taking this medicine.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
  • bleeding or blood disorders
  • HIV-positive or have acquired immunodeficiency syndrome (AIDS)
  • if you frequently drink alcohol-containing drinks
  • infection or weak immune system
  • kidney disease
  • liver disease
  • lung disease
  • stomach ulcers
  • ulcerative colitis
  • an unusual or allergic reaction to methotrexate, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
Can I stop taking the medication if I feel better?
As a general rule, you should always take your medications exactly as prescribed and do not change the dosage or stop taking the medication without first discussing it with your healthcare provider.
I am on so many medications; do I have to take them all?
This is called polypharmacy—many different medications being used at the same time by one person. Sometimes, being on multiple medications is acceptable and appropriate but at other times it may be problematic. If you are receiving your medications from multiple physicians you need to ensure that they all know what medications you are taking. The best way to do this is to make a list of all the medications you are currently using, including all nutritional supplements, homeopathic remedies, vitamins and over-the-counter drugs (if possible, also include all the diseases you have been diagnosed with). Give a copy to every doctor who takes care of you so they have it on file, this way they can avoid duplicating medications and perhaps even try to consolidate some. After every doctor's visit remember to update the list accordingly. Also, as much as you possibly can, try to use the same pharmacy to fill all your prescriptions, this way any potential drug interactions can be caught and averted.
Where can I get more information?
More Information

Follow Yahoo Health on and become a fan on

Follow @YahooHealth on