This information is based on a systematic review of scientific literature, and was peer-reviewed and edited by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ashley Brigham, PharmD (Northeastern University); Nicole Giese, MS (Natural Standard Research Collaboration); Ah Reum Sim, PharmD (Massachusetts College of Pharmacy); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration); Denise Wong, PharmD (Northeastern University).
Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to www.naturalstandard.com. Selected references are listed below.
Arias BA, Ramon-Laca L. Pharmacological properties of citrus and their ancient and medieval uses in the Mediterranean region. J Ethnopharmacol. 2-10-2005;97(1):89-95.
Bailey DG, Dresser GK, Bend JR. Bergamottin, lime juice, and red wine as inhibitors of cytochrome P450 3A4 activity: comparison with grapefruit juice. Clin.Pharmacol.Ther. 2003;73(6):529-537.
Kawaii S, Tomono Y, Katase E, et al. Antiproliferative effects of the readily extractable fractions prepared from various citrus juices on several cancer cell lines. J Agric.Food Chem 1999;47(7):2509-2512.
Garcia OP, Diaz M, Rosado JL, et al. Ascorbic acid from lime juice does not improve the iron status of iron-deficient women in rural Mexico. Am.J.Clin.Nutr. 2003;78(2):267-273.
Gharagozloo M, Ghaderi A. Immunomodulatory effect of concentrated lime juice extract on activated human mononuclear cells. J.Ethnopharmacol. 2001;77(1):85-90.
Gharagozloo M, Doroudchi M, Ghaderi A. Effects of Citrus aurantifolia concentrated extract on the spontaneous proliferation of MDA-MB-453 and RPMI-8866 tumor cell lines. Phytomedicine. 2002;9(5):475-477.
Gill JS, Bhagat CI. Acute copper poisoning from drinking lime cordial prepared and left overnight in an old urn. Med.J.Aust. 5-17-1999;170(10):510.
Imade GE, Sagay AS, Onwuliri VA, et al. Use of lemon or lime juice douches in women in Jos, Nigeria. Sex Health. 2005;2(4):237-9.
Lim SL, Lim LY. Effects of citrus fruit juices on cytotoxicity and drug transport pathways of Caco-2 cell monolayers. Int.J Pharm. 1-3-2006;307(1):42-50.
Lissera RG, Luna Maldonado ER, Battellino LJ. In vitro erosive capacity of some fruit juices and soft or low alcoholic strength beverages on human teeth. Acta Odontol.Latinoam. 1998;11(1):55-71.
Murcia MA, Jimenez AM, Martinez-Tome M. Evaluation of the antioxidant properties of Mediterranean and tropical fruits compared with common food additives. J Food Prot. 2001;64(12):2037-2046.
Paine MF, Criss AB, Watkins PB. Two major grapefruit juice components differ in time to onset of intestinal CYP3A4 inhibition. J Pharmacol Exp.Ther. 2005;312(3):1151-1160.
Rodrigues A, Sandstrom A, Ca T, et al. Protection from cholera by adding lime juice to food - results from community and laboratory studies in Guinea-Bissau, West Africa. Trop.Med.Int.Health 2000;5(6):418-422.
Rodrigues A, Brun H, Sandstrom A. Risk factors for cholera infection in the initial phase of an epidemic in Guinea-Bissau: protection by lime juice. Am.J.Trop.Med.Hyg. 1997;57(5):601-604.
Weber IC, Davis CP, and Greeson DM. Phytophotodermatitis: the other "lime" disease. J Emerg.Med. 1999;17(2):235-237.
Remember, keep this and all other medicines out of the reach of children,
never share your medicines with others, and use this medication only for the indication prescribed.