Sun sensitivity caused by certain drugs like doxycycline or Retin A® may be increased by feverfew. Feverfew may also alter the way that certain drugs are broken down by the liver.
Feverfew may have an additive effect if taken along with drugs taken for cancer, histamine release, fungal or protozoal infections, and drugs that increase blood flow. Feverfew may also interact with anesthetics and antibiotics.
In theory, feverfew may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. This is based on laboratory research, and has not been reported clearly in humans. Multiple cases of bleeding have been reported with the use of Ginkgo biloba and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
Sun sensitivity caused by certain herbs and supplements may be increased by feverfew. Feverfew may alter the way that certain herbs and supplements are broken down by the liver.
Feverfew may theoretically interact with herbs that act as antidepressants, such as St. John's wort.
This information is based on a professional level monograph edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com): Ernie-Paul Barrette, MD (Case Western Reserve University School of Medicine); Ethan Basch, MD, MPhil (Memorial Sloan-Kettering Cancer Center); Dawn Costa, BA, BS (Natural Standard Research Collaboration); Paul Hammerness, MD (Harvard Medical School); Jenna Hollenstein, MS, RD (Natural Standard Research Collaboration); Anh Le, PhD (Emory University); Michael Smith MRPharmS, ND (Canadian College of Naturopathic Medicine); Shaina Tanguay-Colucci, BS (Natural Standard Research Collaboration); Catherine Ulbricht, PharmD (Massachusetts General Hospital); Wendy Weissner, BA (Natural Standard Research Collaboration).