Mesoglycan is likely safe when taken by mouth in doses less than or equal to 200 milligrams daily for 18 months. There is no proven effective dose. However, 96 or 100 milligrams mesoglycan daily by mouth for six months for cerebrovascular disease and hyperlipidemia (high cholesterol) has been used. For intermittent claudication (leg pain), one 24-milligram mesoglycan tablet twice daily for six months has been used. For phlebitis, two 12-milligram mesoglycan capsules three times a day for 30 days has been used. For postphlebitic syndrome, 50 milligrams mesoglycan twice a day for three months has been used.
Mesoglycan is also likely safe when 90 milligrams is injected for 10 days under the supervision of a qualified healthcare professional, including a pharmacist.
Children (younger than 18 years):
There is no proven safe or effective dose for aortic acid in children.
Many complementary techniques are practiced by healthcare professionals with formal training, in accordance with the standards of national organizations. However, this is not universally the case, and adverse effects are possible. Due to limited research, in some cases only limited safety information is available.
There are currently no reported allergic reactions available. Due to the heparan sulfate content of mesoglycan, patients with an allergy to heparin or heparinoid derivatives should use caution.
Side Effects and Warnings
Aortic acid, including mesoglycan, has been well-tolerated for up to 18 months in the available human trials. However, the U.S. Food and Drug Administration (FDA) cautions against the consumption of any dietary supplement made from animal glands or organs, especially from cows and sheep from countries with known cases of bovine spongiform encephalitis (BSE, or "mad cow" disease) or scrapie. It is thought that these extracts may contain viable prions that could infect humans. Currently, there are no available reports of transmission of BSE through aortic acid.
Mesoglycan (injection or taken by mouth) has caused minor side effects including diarrhea, headache.