Acemannan, Aloe africana, Aloe arborescens Miller, Aloe barbadensis, Aloe barbadesis, Aloe capensis, aloe-coated gloves, Aloe ferox, aloe latex, aloe mucilage, Aloe perfoliata, Aloe perryi Baker, Aloe saponaria, Aloe spicata, Aloe vulgari, Barbados aloe, bitter aloe, burn plant, Cape aloe, Carrisyn, Curaçao aloe, elephant's gall, first-aid plant, Ghai kunwar, Ghikumar, hirukattali, Hsiang-Dan, jelly leek, kumari, lahoi, laloi, lily of the desert, Lu-Hui, medicine plant, Mediterranean aloe, miracle plant, mocha aloes, musabbar, natal aloes, nohwa, plant of immortality, plant of life, rokai, sabilla, Savila, Socotrine aloe, subr, true aloe, Venezuela aloe, Za'bila, Zanzibar aloe.
Transparent gel from the pulp of the meaty leaves of Aloe vera has been used topically for thousands of years to treat wounds, skin infections, burns, and numerous other dermatologic conditions. Dried latex from the inner lining of the leaf has traditionally been used as an oral laxative.
There is strong scientific evidence in support of the laxative properties of aloe latex, based on the well-established cathartic properties of anthroquinone glycosides (found in aloe latex). However, aloe's therapeutic value compared with other approaches to constipation remains unclear.
There is promising preliminary support from laboratory, animal, and human studies that topical aloe gel has immunomodulatory properties that may improve wound healing and skin inflammation.
Dried latex from the inner lining of aloe leaves has been used traditionally as a laxative taken by mouth. Although few studies have been conducted to assess this effect of aloe in humans, the laxative properties of aloe components such as aloin are well supported by scientific evidence. A combination herbal remedy containing aloe was found to be an effective laxative, although it is not clear if this effect was due to aloe or to other ingredients in the product. Further study is needed to establish dosing and to compare the effectiveness and safety of aloe with other commonly used laxatives.
Limited evidence from human studies suggests that extract from Aloe vera in a hydrophilic cream may be an effective treatment of genital herpes in men (better than aloe gel or placebo). Additional research is needed in this area before a strong recommendation can be made.
Early evidence suggests that an extract from aloe in a hydrophilic cream may be an effective treatment of psoriasis vulgaris. Additional research is needed in this area before a strong recommendation can be made.
Seborrheic dermatitis (seborrhea, dandruff):
Early study of aloe lotion suggests effectiveness for treating seborrheic dermatitis when applied to the skin. Further study is needed in this area before a strong recommendation can be made.
There is early evidence that oral aloe may reduce the risk of developing lung cancer. Further study is needed in this area to clarify if it is aloe itself or other factors that may cause this benefit.
Canker sores (aphthous stomatitis):
There is weak evidence that treatment of recurrent aphthous ulcers of the mouth with aloe gel may reduce pain and increase the amount of time between the appearance of new ulcers. Further study is needed before a firm recommendation can be made.
Diabetes (type 2):
Study results are mixed. More research is needed to explore the effectiveness and safety of aloe in diabetics.
Traditionally, aloe has been used as a moisturizer. Early low-quality studies suggest aloe may effectively reduce skin dryness. Higher quality studies are needed in this area.
Without further human trials, the evidence cannot be considered convincing either in favor or against this use of aloe.
Limited study suggests that aloe may be a helpful, safe treatment for lichen planus, which is a chronic inflammatory disease that affects the lining of the mouth. Additional study is needed.
Early evidence suggests that aloe may aid healing of mild to moderate skin burns. Further study is needed in this area.
Early studies suggest aloe may help heal skin ulcers. High-quality studies comparing aloe alone with placebo are needed.
Ulcerative colitis (including inflammatory bowel disease):
There is limited but promising research of the use of oral aloe vera in ulcerative colitis (UC), compared to placebo. It is not clear how aloe vera compares to other treatments used for UC.
Study results of aloe on wound healing are mixed with some studies reporting positive results and others showing no benefit or potential worsening of the condition. Further study is needed, since wound healing is a popular use of topical aloe.
There is early evidence that oral aloe vera does not prevent or improve mucositis (mouth sores) associated with radiation therapy.
Early well-designed studies in humans found no benefit of topical acemannan hydrogel (a component of aloe gel) in the treatment of pressure ulcers.
Reports in the 1930s of topical aloe's beneficial effects on skin after radiation exposure lead to widespread use in skin products. Currently, aloe gel is sometimes recommended for skin irritation caused by prolonged exposure to radiation, although scientific evidence suggests a lack of benefit in this area.