The anterior superior pancreaticoduodenal artery branches off the gastroduodenal artery and curves downward, to the left. It is specifically located on the pancreas head's anterior surface, partially buried under the pancreatic parenchyma. It supplies the pancreas' and duodenum's anterior margins with blood.
The anterior superior pancreaticoduodenal artery is different from the inferior pancreaticoduodenal artery, which branches off the superior mesenteric artery. Together these arteries work with the splenic artery's pancreatic branches form connections with each other. The anastomoses process that these arteries go through allows blood to enter the duodenum and pancreas from various channels.
Anterior superior pancreaticoduodenal artery aneurysms account for two percent of total splanchnic circulation aneurysms. These aneurysms are normally the result of hemodynamic stress caused by increased blood flow in return for the superior mesenteric artery's occlusion. Because the anterior superior pancreaticoduodenal artery is difficult to access, open surgery is required for aneuresectomies in this area. Transcatheter arterial embolization can also effectively treat an aneurysmal rupture of the anterior superior pancreaticoduodenal artery.