What is this medicine?

POSACONAZOLE (POE sa KON a zole) is an antifungal medicine. It is used to treat or prevent certain kinds of fungal or yeast infections.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• kidney disease
• liver disease
• take an ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
• take astemizole, cisapride, halofantrine, pimozide, quinidine, or terfenadine
• an unusual or allergic reaction to posaconazole, antifungals, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Shake well before using. Take with a full meal or liquid nutritional supplement. Use a specially marked spoon or dropper to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think you are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 13 years old for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

• cisapride
• ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
• pimozide
• quinidine
• red yeast rice
• sirolimus

This medicine may also interact with the following medications:

• atazanavir
• cimetidine
• cyclosporine
• digoxin
• efavirenz
• medicines for blood pressure like amlodipine, diltiazem, verapamil
• midazolam
• phenytoin, fosphenytoin
• rifabutin
• ritonavir-some medicines for anxiety or sleep like alprazolam, clorazepate, flurazepam, midazolam, triazolam
• some medicines for cancer like vinblastine, vincristine
• some medicines for cholesterol like atorvastatin, cerivastatin, lovastatin, simvastatin
• tacrolimus

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.