What is this medicine?

HISTRELIN (his TREL in) is used to treat the symptoms of advanced prostate cancer. The implant contains a drug that is like a natural hormone in the body called gonadotropin-releasing hormone (GnRH). It is placed under the skin and releases the drug over 12 months.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• female (this implant is not for use in women)
• pain or trouble passing urine
• spinal cord metastasis
• an unusual or allergic reaction to histrelin, other medicines, foods, dyes, or preservatives

How should I use this medicine?

This medicine is placed under the skin of your arm by a health care professional in a clinic or office. After the implant is placed, keep the insertion site clean and dry for 24 hours. Avoid heavy lifting and strenuous exercise for 7 days after implant insertion. The surgical strips over the site should be allowed to fall off on their own over several days. The implant must be removed after 12 months. At this time, a new implant may be inserted to continue therapy.

Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply. After 1 year, the implant will have to be removed. If you need to continue this medicine, the implant will be replaced at that time.

What may interact with this medicine?

• female hormones, like estrogens or progestins and birth control pills, patches, rings, or injections
• herbal or dietary supplements, like black cohosh or DHEA
• male hormones, like testosterone
• medicines for depression, anxiety, or psychotic disturbances
• prasterone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.