What is this medicine?

ANTITHROMBIN III (AN te throm bin) is a natural protein. It is used to treat patients with low levels of antithrombin III. People with this condition may have an increased risk for developing blood clots, especially during surgery or during pregnancy. This medicine may help to reduce the risk for blood clots or help to treat blood clots once they have already developed.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• an unusual or allergic reaction to antithrombin III, goat or goat milk proteins, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

• aspirin and aspirin-like drugs
• medicines that treat or prevent blood clots like warfarin or heparin
• mifepristone

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Your condition will be closely monitored while you are receiving this medicine. Tell your doctor or health care professional if you experience any adverse effects while you are receiving this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• chest tightness or chest pain
• itching or hot feeling around the injection site
• unusual bleeding or bruising like bleeding gums, red spots on the skin, nosebleeds, blood in the stool or urine
• unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• dizziness

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.