What is this medicine?

AMILORIDE; HYDROCHLOROTHIAZIDE (a MIL oh ride; hye droe klor oh THYE a zide) is a combination of two types of diuretics. It helps you make more urine and to lose excess water from your body. This medicine is used to treat high blood pressure and heart failure.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• diabetes
• immune system problems, like lupus
• kidney disease
• small amount of urine
• unusual or allergic reaction to amiloride, hydrochlorothiazide, other diuretics, sulfa drugs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Take it at regular intervals. Remember that you will need to pass urine frequently after taking this medicine. Do not take your doses at a time of day that will cause you problems. Do not take at bedtime. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

• eplerenone
• potassium sparing diuretics
• quinidine

This medicine may also interact with the following medications:

• ACE inhibitors for heart or kidney disease like captopril, lisinopril
• antiinflammatory drugs, NSAIDs like ibuprofen
• alcohol
• barbiturate medicines for sleep or seizure control
• cholestyramine, colestipol
• cyclosporine
• lithium
• medicines for diabetes
• medicines for high blood pressure or heart failure
• muscle relaxers
• neuromuscular blockers used during surgery
• other diuretics
• potassium supplements
• some medicines for pain like codeine
• steroid hormones like cortisone, hydrocortisone, prednisone
• tacrolimus

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.