Depomedroxyprogesterone acetate (MPA) has been reviewed and found, at doses of 150 mg every one to two months [as an injection], for women with endometrial cancer to be 85% effective in reducing hot flashes when compared with estrogen. Oral doses of 10 mg/day were 87% effective. Reported side effects included: irregular vaginal bleeding, weight gain and bloating, breast tenderness and mood swings.
Blood pressure medications (antihypertensives)
Blood pressure medications—alpha-adrenergic agonist antihypertensives—that inhibit the stress trigger pathways involved in hot flashes, reduce hot flashes 20% to 65%. Drugs and dosages used include: clonidine, at 0.05–0.2 mg/day; lefoxidine, at 0.1 mg/day; and methyldopa, at 250 mg three times daily. Side effects of dizziness and dry mouth were reported.
The twice daily use of 40 mg of bellergal—a potent hypnotic-sedative combination of ergotamine tartrate, belladona alkaloids, and phenobarbitol—reduces hot flashes by 60% when compared to the placebo rate of 22%. This drug is one of the older synthetic remedies prescribed for hot flashes, due to its effects on the nervous system. It has the very undesirable effect of being addictive, and avoidance of alcohol is strongly advised.
One of the newer drugs for relief of hot flashes, studied under rigorous clinical trial according to one source, a 20 mg twice daily oral dose, megestrol acetate is considered to show high promise for use in both men and women. It is considered as a treatment for breast cancer in high continuous doses. Initial dosing is reported to start at 40 mg daily, and then be tapered up or down after a month, to a maximum of 80 mg daily. Side effects noted were fluid retention and bloating.
Katherine E. Nelson N.D., The Gale Group Inc., Gale, Detroit,