—Repeat tissue typing to confirm the compatibility of the donor and patient before transplant
—A healthy person who contributes bone marrow for transplantation.
Graft versus host disease
—A life-threatening complication of bone marrow transplants in which the donated marrow causes an immune reaction against the recipient's body.
—The major histocompatibility determinants are the human leukocyte antigens (HLA) and characterize how well the patient and donor are matched.
HLA (human leuckocyte antigen)
—A group of protein molecules located on bone marrow cells that can provoke an immune response. A donor's and a recipient's HLA types should match as closely as possible to prevent the recipient's immune system from attacking the donor's marrow as a foreign material that does not belong in the body.
—A type of cancer involving the lymph nodes and potentially affecting nonlymphatic organs in the later stage.
—A disorder in which the immune system is ineffective or disabled either due to acquired or inherited disease.
—A type of cancer that affects leukocytes, a particular type of white blood cell. A characteristic symptom is excessive production of immature or otherwise abnormal leukocytes.
—A type of cancer that affects lymph cells and tissues, including certain white blood cells (T cells and B cells), lymph nodes, bone marrow, and the spleen. Abnormal cells (lymphocyte/leukocyte) multiply uncontrollably.
—How similar the HLA typing, out of a possible six antigens, is between the donor and the recipient.
Mixed lymphocyte culture (MLC)
—Test that measures level of reactivity between donor and recipient lymphocytes.
—Solid tumor in children, may be treated by BMT.
—Fragments of a large precursor cell, a megakaryocyte found in the bone marrow. These fragments adhere to areas of blood vessel damage and release chemical signals that direct the formation of a blood clot.
Julia Barrett, Laura Ruth Ph.D., The Gale Group Inc., Gale, Detroit,