Antiulcer Drugs Health Article

Interactions

Proton pump inhibitors may increase the pH of the stomach. This will inactivate some antifungal drugs that require an acid medium for effectiveness, notable itraconazole and ketoconazole.

H-2 receptor blocking agents have a large number of drug interactions. Consult individualized references.

Sucralfate should not be used with aluminum containing antacids, because of the risk of increased aluminum absorption. Sucralfate may inhibit absorption and reduce blood levels of anticoagulants, digoxin, quinidine, ketoconazole, quinolones and phenytoin.

ORGANIZATIONS

Digestive Disease National Coalition. 507 Capitol Court NE, Suite 200, Washington, DC 20003. (202) 544-7497.

National Digestive Diseases Information Clearinghouse. 2 Information Way, Bethesda, MD 20892-3570. nddic@aerie.com. <http://www.niddk.nih.gov/Brochures/NDDIC.htm>.

OTHER

Duodenal Ulcer Fact sheet. Johns Hopkins Health Information Adult Health Advisor. Available at <http://csi.intelihealth.com>.

National Institute of Diabetes and Digestive and Kidney Diseases. <http://www.niddk.nih.gov>.

PharmInfoNet's Digestive Disease Center. <http://pharminfo.com/disease.gastro.html>.

Stomach and Duodenal Ulcers. Fact sheet. National Institute of Diabetes and Digestive and Kidney Diseases, January 1995 (NIH Publication No. 95-38).

Stomach Ulcer (Gastric Ulcer). Fact sheet. Johns Hopkins Health Information Adult Health Advisor. Available on website at <http://csi.intelihealth.com>.

Samuel Uretsky, PharmD

KEY TERMS

Antibiotic—Medicine used to treat infections.

Enzyme—A type of protein, produced in the body, that brings about or speeds up chemical reactions.

Gastrointestinal tract—The stomach, small intestine and large intestine.

Hypersecretory—Excessive production of a bodily secretion. The most common hypersecretory syndrome of the stomach is Zollinger-Ellison Syndrome, a syndrome consisting of fulminating intractable peptic ulcers, gastric hypersecretion and hyperacidity, and the occurrence of gastrinomas of the pancreatic cells of the islets of Langerhans.

Inflammation—Pain, redness, swelling, and heat that usually develop in response to injury or illness.

Mucous—Thick fluid produced by the moist membranes that line many body cavities and structures.

Nonsteroidal anti-inflammatory drug (NSAID)— A type of medicine used to relieve pain, swelling, and other symptoms of inflammation, such as ibuprofen or ketoprofen.