There are no treatments that have been proved effective in most cases of amnestic disorder, as of 2002. Many patients recover slowly over time, and sometimes recover memories that were formed before the onset of the amnestic disorder. Patients generally recover from transient global amnesia without treatment. In people judged to have the signs that often lead to alcohol-induced persisting amnestic disorder, treatment with thiamin may stop the disorder from developing.
Amnestic disorders caused by alcoholism do not generally improve significantly over time, although in a small number of cases the patient's condition improves completely. In many cases the symptoms are severe, and in some cases warrant long-term care for the patient to make sure his or her daily needs are met. Other substance induced amnestic disorders have a variable rate of recovery, although in many cases full recovery does eventually occur. Transient global amnesia usually resolves fully.
Amnestic disorders resulting from trauma are not generally considered preventable. Avoiding exposure to environmental toxins, refraining from abuse of alcohol or other substances, and maintaining a balanced diet may help to prevent some forms of amnestic disorders.