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Anti-Mullerian Hormone and Fertility

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There are several markers of a women’s reproductive health when it comes to making a baby. Many are familiar with common hormone tests such as estrogen, progesterone and the follicle-stimulating hormone (FSH).

New research is showing that the anti-Mullerian hormone (AMH) might be a better predictor for those looking to undergo in vitro fertilization (IVF). However, it may also be advantageous to check this marker when looking to become pregnant in general.

To compare, the FSH test is essentially a marker of communication between the anterior pituitary in the brain down to the ovaries.

When the FSH begins to rise on day 2 or 3 of the cycle, it stimulates the growth and development of the follicles such that a dominant follicle is formed, and with the trigger of luteinizing hormone, an egg can be released for pregnancy.

As a woman becomes older, her FSH levels rise as there are fewer and fewer follicles left in the ovary, yet the pituitary continues to produce the hormone. The higher the FSH levels (typically above 10), the less fertile a woman has become.

Working with FSH is the anti-Mullerian hormone. AMH is produced directly by the ovaries in order to help with follicular development as well, by controlling excessive follicle stimulation by FSH.

Those with lower AMH are thought to have lower levels of follicles. Therefore the potential for egg development is a lot less.

Unlike the FSH marker which should be drawn on Day 2 or 3 of the menstrual cycle, the AMH can be checked any day, as it does not typically vary throughout the month.

Research reported in the February 2013 Journal of Clinical Endocrinology and Metabolism suggested that AMH is a good predictive marker for those women looking to undergo IVF. This is because it can predict the oocyte (immature egg cell) yield and oocyte quality, which is important for a successful transfer.

The higher the AMH level (typically between 3-7 ng/mL depending on the lab and fertility center) the better the outcome for IVF, which means a successful pregnancy.

Levels above 7ng/mL are indicative of PCOS. Levels less than 2 ng/mL are indicative of lower fertility chances.

If you are currently trying to become pregnant, are having difficulty becoming pregnant or are thinking about it for the future, remember that you are more than a number.

These tests may be powerful indicators of what’s to come, but there are several factors that contribute to the health of your body, ovaries and eggs.

Talk with your health care provider about getting a workup and remember to work towards being as healthy as you can be when it comes to making a baby.

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